Tolerance to Carsil (Silymarin)
TOLERANCE TO CARSIL Toxicological studies The acute, subacute and chronic toxicity was studied. The toxic effects of Carsil were studied on laboratory animals: mice, rats and dogs. ACUTE TOXICITY No lethality was observed after administration of single oral doses as high as 20,000 mg/kg to mice and rats. No behavioral change and lethality were observed after administration of oral doses as high as 1,000 mg/kg to dogs. SUBACUTE AND CHRONIC... read more ››
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Silymarin substance
SILYMARIN
DESCRIPTIONA drug of plant origin with hepatoprotective action. The active component of Carsil, Silymarin stabilizes the cell membrane of the liver and stimulates protein synthesis, which restores the functions of the damaged cells and protects the liver parenchyma from destructive action of noxae.
MOLECULAR MASS: (Silymarin main component) 500.47
PHYSICOCHEMICAL INDICES OF THE FINISHED PRODUCT
¤ Appearance
amorphous powder
¤ Color
yellow to yellow-brown
¤... read more ››
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Carsil Pharmacological Studies
PHARMACOLOGICAL STUDIES Studies on laboratory animal models of liver intoxication, comparable to the human liver diseases, have been performed in order to prove the hepatoprotective effect of Carsil®. 1. Intoxication with tetrachlormethane: resembles human hepatitis histologically. On the background of the above intoxication, Carsil® acts through reduction of the liver adipose infiltration, and consolidation of the cell membranes, which results in normalized... read more ››
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Tolerance to Carsil (Silymarin)
TOLERANCE TO CARSIL Toxicological studies The acute, subacute and chronic toxicity was studied. The toxic effects of Carsil were studied on laboratory animals: mice, rats and dogs. ACUTE TOXICITY No lethality was observed after administration of single oral doses as high as 20,000 mg/kg to mice and rats. No behavioral change and lethality were observed after administration of oral doses as high as 1,000 mg/kg to dogs. SUBACUTE AND CHRONIC... read more ››
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Carsil mechanism of action
MECHANISM OF ACTION
The anti-hepatotoxic effect of Silymarin is associated with the competitive interaction with the receptors of the relevant toxins in the hepatocyte membrane, and with a more general action of protective nature (Vogel 1975).
So, the hepatoprotective action of Carsil® (with Silymarin as generic name) is manifested by a consolidation of the membranes and the functions of the cell structures. Thus, a specific protective and curative effect on the liver protective function in... read more ››
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Carsil a Result of a Natural Product
CARSIL - A RESULT OF A NATURAL PRODUCT
Carsil is a flavonoid mixture isolated from Silybum marianum.
The white thorn is an annual or biennial herbaceous plant, whit a height of 20-150 cm and weak branching. The plant grows in weedy places near populated locations. It can be found in Southwestern and Southern Europe, and it is cultivated and naturalized in locations of Western and Central Europe.
The fruits if the white thorn are a drug (Semen Silybi).
A flavonoid... read more ››
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Carsil Indications
INDICATIONS
In chronic liver inflammation, liver dystrophy, cirrhosis, adipose degeneration resulting from hepatitis, liver impairment with functional disorders caused by poisoning, and as a prophylactic agent in cases of an increased inflow of liver function loading substances.
POSITION OF CARSIL IN THE COMPREHENSIVE THERAPY OF:
Liver cirrhosis
Carsil has a good effect in the therapy of liver cirrhosis, too. The pathological biochemical values become normal in a high percentage of the cases.... read more ››
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Clinical use of Carsil
CLINICAL USE OF CARSILCarsil is appropriate in patients with liver steatosis, chronic hepatitis, hepatic cirrhosis, toxic metabolic liver damage, liver adipose degeneration, but also as a hepatoprotective agent in case of administration of liver-loading substances.The judgment of the effect of the liver therapeutic agents is rather problematic. On the one hand due to the substantial spontaneous inter-individual fluctuations of the course of... read more ››
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Carsil (Silymarin) for Liver Conditions
Carsil (Silymarin) for Liver Conditions
Carsil is a product of plant origin with hepatoprotective and antioxidative action. The active component of Carsil is Silymarin derived from Silibum Marianum (Milk Thistle, Bulgarian White Thorn). Silymarin, as the plant active ingredient of Carsil, has a consolidating effect on the cell membrane, thus protecting the liver from harmful impacts and facilitating the recovery of the impaired... read more ››
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